Introduction. Gastrointestinal bleeding represents the main indication for emergency endoscopy (EE). Lately, several hemostatic\npowders have been released to facilitate EE. Methods. We evaluated all EE in which Hemospray was used as primary or salvage\ntherapy, with regard to short- and long-term hemostasis and complications. Results. We conducted 677 EE in 474 patients (488\nexaminations in 344 patientswere upperGI endoscopies).Hemospray was applied during 35 examinations in 27 patients (19 males),\n33 during upper and 2 during lower endoscopy. It was used after previous treatment in 21 examinations (60%) and in 14 (40%) as\nsalvage therapy. Short-termsuccess was reached in 34 of 35 applications (97.1%),while long-termsuccess occurred in 23 applications\n(65.7%). Similar long-term results were found after primary application (64,3%) or salvage therapy (66,7%). Rebleeding was found\nin malignant and extended ulcers. One major adverse event (2.8%) occurred with gastric perforation after Hemospray application.\nDiscussion. Hemospray achieved short-termhemostasis in virtually all cases. The long-termeffect is mainly determined by the type\nof bleeding source, but not whether it was applied as first line or salvage therapy. But, even in the failures, patients had benefit from\nhemodynamic stabilization and consecutive interventions in optimized conditions.
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